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Who is a Partial Responder? Patients who have experienced response following antidepressant therapy but who still have symptoms of depression and no longer show any further sign of improvement after an extended period of treatment

When is TMS Indicated? KEY FINDINGS FROM THE LARGEST EVER NIMH DEPRESSION TREATMENT STUDY •The NIMH-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Study was conducted to determine the effectiveness of different treatments for people with major depression who have not responded to initial treatment with an antidepressant. 1 • The outcome measure was a “remission” of depressive symptoms—becoming symptom-free. This outcome was selected because people who reach this goal generally function better socially and at work, and have a better chance of staying well than do people who only achieve a response but not a remission . 2 • With 4,041 adult outpatients from 41 clinical sites around the country, over a 7 year period, STAR*D is the largest and longest study ever conducted to evaluate depression treatment. 3 • Significantly, STAR*D found that the likelihood  of achieving remission on the 3rd or 4th medication is <25%. 4 Transcranial Magnetic Stimulation (TMS) is cleared by the U.S. Food and Drug Administration (FDA) for major depressive disorder (MDD) in patients who have not responded to 1 adequate antidepressant trial in the current episode. 6 (1) https://www.nimh.nih.gov/funding/clinical-research/practical/stard/ (2) https://www.nimh.nih.gov/funding/clinical-research/practical/stard/allmedicationlevels (3) Ibid. (4) Ibid. (5) HAMD 17, also known as the Hamilton Depression Rating Scale (HDRS), is a widely used 17 question clinician-administered depression assessment scale (6) O’Reardon et al., 2012 Apr, PMID: 22579164

How TMS Works MECHANISM OF ACTION A magnetic coil is placed over the dorsolateral prefrontal cortex The coil delivers magnetic pulses into the brain TMS activates neurons in areas of the brain that are not functioning correctly due to depression Pulses trigger electrical currents that release neurotransmitters • Uses MRI-strength magnetic coil • Aids neuroplasticity with minimal side effects (scalp sensitivity or mild headaches) • On average, patients begin to see treatment impact at week 2* 6 WEEKS 5 DAYS EACH WEEK 20 MINUTES AVERAGE TREATMENT PLAN** *Results may very **Treatment plan may vary depending on doctor’s recommendations

8 Things to know about TMS, How TMS Works and TMS for OCD

Greenbrook TMS Patient Journey HOW WE CAN HELP Transcranial Magnetic Stimulation (TMS) is an FDA-cleared, non-invasive therapy for the treatment of Major Depressive Disorder (MDD) & Obsessive Compulsive Disorder in patients that have failed drug treatments or have not reached full remission from symptoms. No-Cost Consultation Meeting with a Patient Consultant to learn about the TMS therapy treatment process and start insurance paperwork if needed Pre-Assessment Office visit with a Greenbrook TMS affiliated psychistrist to evaluate whether TMS is right for your patient Motor Threshold A Greenbrook TMS affiliated psychistrist identifies the precise areas of the brain associated with depression, and establishes your patient’s unique treatment settings TMS Treatment • Daily 18-45 minute sessions • During treatment, patient can watch TV, read, use their phone • Patients typically feel an improvement within 3 to 4 weeks Post-Treatment Office Visit Based on their results, your patient’s TMS provider will make recommendations for further care to you and your patient We keep you informed throughout your patient’s journey Tremendous efficacy and safety profile validated through multiple studies Dedicated Care team with 24/7 access to Clinical Advisory Commitee, including Chief Medical Officer We handle all aspects of your patient’s TMS treatment experiences, including insurance authorizations Greenbrook TMS therapy covered by many major insurance companies 

About Greenbrook TMS and the Patient Journey

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